Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → [4-(Methanesulfonylaminocarbonyl)butyl]triphenylphosphonium bromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 5-Bromo-N-methanesulfonylpentanamide | HCID 20296141 | — |
| 반응물 | Ethylacetate acetone | HCID 21584569 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | [4-(Methanesulfonylaminocarbonyl)butyl]triphenylphosphonium bromide | HCID 19608840 | 78% |
반응 단계
A stirring mixture consisting of triphenylphosphine (13.2 g, 24.4 mmol) and 5-bromo-N-(methylsulfonyl)pentanamide (prepared in Step A, 5.55 g, 21.5 mmol) in xylene (15 mL) was brought to reflux for 4 hours. Subsequently, ethyl acetate was added to the hot reaction mixture and stirring was continued for the next 15 minutes. The crude product was isolated from acetone-ethyl acetate to afford the title intermediate (8.68 g, 78%); melting point 189-190° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063240B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-62de46e6eef545028d030342528bad0f |
| 출처 메모 | uspto-grants-2011_11 |