Sulfuryl chloride → 2-Chloro-3-hydroxy-5-(3-methoxypropyl)benzaldehyde
반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][O:13][CH3:14])[CH:9]=1)[CH:5]=[O:6].S(Cl)([Cl:18])(=O)=O>ClCCl>[Cl:18][C:3]1[C:2]([OH:1])=[CH:9][C:8]([CH2:10][CH2:11][CH2:12][O:13][CH3:14])=[CH:7][C:4]=1[CH:5]=[O:6]참가 물질
4
실험 절차
To a solution of 3-hydroxy-5-(3-methoxypropyl)benzaldehyde from the previous step (I eq.) in dichloromethane (0.2 M) was added sulfuryl chloride (1 eq.). The resulting reaction mixture was then stirred at RT for 18 h. The volatiles were removed in vacuo and purification of the crude product thus obtained by way of column chromatography (SiO2, Hex→3:2 (v/v) Hex:EtOAc) afforded the title compound as a yellow oil.
후처리
- customThe resulting reaction mixture
- customThe volatiles were removed in vacuo and purification of the crude product
- customthus obtained by way of column chromatography (SiO2, Hex→3:2 (v/v) Hex:EtOAc)
출처 및 근거
- ORD 기록
- ord-d0a826634e2041c2b467da77ad815ef4
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08063105B2
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