Beta-Propiolactone → 3-(2-Bromo-3-formylphenoxy)propanoic acid

HRID 561837노트

반응식

HRID 561837 반응식
[Br:1][C:2]1[C:9]([OH:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].CC(C)([O-])C.[K+].[O:17]1[CH2:20][CH2:19][C:18]1=[O:21]>C1COCC1>[Br:1][C:2]1[C:3]([CH:4]=[O:5])=[CH:6][CH:7]=[CH:8][C:9]=1[O:10][CH2:20][CH2:19][C:18]([OH:21])=[O:17]

참가 물질

5

반응물 3

HCID 2365Beta-PropiolactoneHCID 37146742-Bromo-3-hydroxybenzaldehydeHCID 23665647Potassium tert-butoxide

생성물 1

HCID 866359223-(2-Bromo-3-formylphenoxy)propanoic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-bromo-3-hydroxybenzaldehyde (1 eq.) in THF (1.2 M) was added sequentially potassium tert-butoxide (1.0 M THF solution, 0.8 eq.) and oxetan-2one at RT. The resulting yellow suspension was stirred at RT for 16 h. The reaction mixture was quenched with 10% aq. HCl and extracted with EtOAc. The combined organic extracts were washed with water and brine. Drying over MgSO4, filtration and concentration of the filtrate in vacuo afforded the title compound as a white solid.

후처리

  1. customThe reaction mixture was quenched with 10% aq. HCl
  2. extractionextracted with EtOAc
  3. washThe combined organic extracts were washed with water and brine
  4. dry with materialDrying over MgSO4, filtration and concentration of the filtrate in vacuo

출처 및 근거

ORD 기록
ord-3c08bec7f5174473a104ee045e6356f4
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063105B2

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