Potassium Carbonate → 2-fluoro-4-nitro-N-(2-(piperidin-1-yl)ethyl)aniline

HRID 56187

반응식

HRID 56187 반응식
[N:1]1([CH2:7][CH2:8][NH2:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].F[C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][C:18]=1[F:26]>CC(C)=O>[F:26][C:18]1[CH:19]=[C:20]([N+:23]([O-:25])=[O:24])[CH:21]=[CH:22][C:17]=1[NH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 33944N-(2-Aminoethyl)piperidineHCID 1230531,2-Difluoro-4-nitrobenzene

생성물 1

HCID 523235752-fluoro-4-nitro-N-(2-(piperidin-1-yl)ethyl)aniline

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a suspension of 2-(piperidin-1-yl)ethanamine (0.90 g, 7.02 mmol) and K2CO3 (0.97 g, 7.02 mmol) in acetone (30 mL) was added 1,2-difluoro-4-nitrobenzene (1.11 g, 6.98 mmol) in one portion in an ice bath and the mixture was refluxed overnight, cooled to rt and filtered. The filtrate was concentrated in vacuo to give the crude product, which was used for next step without further purification.

후처리

  1. temperaturethe mixture was refluxed overnight
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-21db24e4e1534aff9214e05e442c933c
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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