1-(2-Fluoro-4-iodo-phenyl)-ethanol → 2'-Fluoro-4'-iodoacetophenone

HRID 561962노트

반응식

HRID 561962 반응식
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[CH:9]([OH:11])[CH3:10]>ClCCl.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10]

참가 물질

4

반응물 1

HCID 534154531-(2-Fluoro-4-iodo-phenyl)-ethanol

생성물 1

HCID 534154542'-Fluoro-4'-iodoacetophenone수율 91.3%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of 1-(2-fluoro-4-iodo-phenyl)-ethanol (15.50 g, 58.26 mmol) in dichloromethane (250 mL) was added manganese dioxide (101.26 g, 1.17 mole) and the reaction mixture was heated to reflux for 24 hours. The reaction mixture was cooled, filtered through a pad of celite coated with a thin layer of silica gel and concentrated in vacuo to give 1-(2-fluoro-4-iodo-phenyl)-ethanone (14.04 g, 91%).

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 24 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationfiltered through a pad of celite coated with a thin layer of silica gel
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-b0979d46b68d4c4dbb22e9005ec959b9
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063085B2

반응 노트

불러오는 중…