But-1-ene-1,3-dione → N-(3-chloro-4-(dihexylamino)phenyl)-3-oxobutanamide

HRID 56198노트

반응식

HRID 56198 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[N:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[C:22]([CH:25]=[C:26]=[O:27])(=[O:24])[CH3:23]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:26](=[O:27])[CH2:25][C:22](=[O:24])[CH3:23])[CH:5]=[CH:4][C:3]=1[N:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

참가 물질

4

반응물 2

HCID 12642904But-1-ene-1,3-dioneHCID 1179660622-chloro-N1,N1-dihexylbenzene-1,4-diamine

생성물 1

HCID 90023042N-(3-chloro-4-(dihexylamino)phenyl)-3-oxobutanamide수율 100%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
80 °C

실험 절차

To a solution of 2-chloro-N1,N1-dihexylbenzene-1,4-diamine (3.11 g, 10 mmol) in toluene (50 mL) was added acetyl ketene (1.68 g, 20 mmol) and the mixture was stirred at 80° C. overnight. The mixture was cooled to rt and concentrated in vacuo to give the title compound as blackish oil (3.94 g, 100%).

후처리

  1. temperatureThe mixture was cooled to rt
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-51ab07dd89b54868b4347755c0f77952
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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