Ammonia → (Z)-3-amino-N-(3-cyano-4-(dihexylamino)phenyl)but-2-enamide

HRID 56208노트

반응식

HRID 56208 반응식
[C:1]([C:3]1[CH:4]=[C:5]([NH:22][C:23](=[O:28])[CH2:24][C:25](=O)[CH3:26])[CH:6]=[CH:7][C:8]=1[N:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])#[N:2].[NH3:29]>CO>[NH2:29]/[C:25](/[CH3:26])=[CH:24]\[C:23]([NH:22][C:5]1[CH:6]=[CH:7][C:8]([N:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[C:3]([C:1]#[N:2])[CH:4]=1)=[O:28]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 90023598N-(3-cyano-4-(dihexylamino)phenyl)-3-oxobutanamide

생성물 1

HCID 90022969(Z)-3-amino-N-(3-cyano-4-(dihexylamino)phenyl)but-2-enamide수율 88%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of N-(3-cyano-4-(dihexylamino)phenyl)-3-oxobutanamide (1.47 g, 3.81 mmol), MeOH (15 mL) and ammonia (15 mL) was stirred at rt overnight. The mixture was concentrated in vacuo to give the title compound as black oil (1.30 g, 88%).

후처리

  1. concentrationThe mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-af8d51602c5843c0afb91c84da09b43c
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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