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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 562254생성일: 2026년 10월 26일

2-(5-Bromothiophen-2-yl)piperazine → 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[4-(2-piperazinyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate

https://huagongshe.com/reaction/562254

반응식

참여 물질

역할이름HCID투입량
반응물2-(5-Bromothiophen-2-yl)piperazineHCID 19763606—
반응물3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[5-(2-piperazinyl)-2-thienyl]-1H-indole-7-carboxamide trifluoroacetateHCID 66723302—
생성물3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[4-(2-piperazinyl)phenyl]-1H-indole-7-carboxamide trifluoroacetateHCID 6672294825.9%

반응 단계

The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[5-(2-piperazinyl)-2-thienyl]-1H-indole-7-carboxamide trifluoroacetate, substituting 2-(4-bromophenyl)piperazine (94 mg, 0.39 mmol) for 2-(5-bromo-2-thienyl)piperazine to afford 20.5 mg of the title compound (25.9%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08063071B2
출처 데이터셋uspto-grants-2011_11
ORD IDord-25819822f188489b9d71177f0c149c92
출처 메모uspto-grants-2011_11