Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(S)-(+)-Tetrahydrofurfurylamine → 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(3-fluoro-5-{[(2-methylbutyl)amino]methyl}phenyl)-1H-indole-7-carboxamide trifluoroacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (S)-(+)-Tetrahydrofurfurylamine | HCID 641530 | — |
| 반응물 | 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-fluoro-5-({[(2S)-tetrahydro-2-furanylmethyl]amino}methyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate | HCID 66723136 | — |
| 생성물 | 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(3-fluoro-5-{[(2-methylbutyl)amino]methyl}phenyl)-1H-indole-7-carboxamide trifluoroacetate | HCID 66723163 | 54.5% |
반응 단계
The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-fluoro-5-({[(2S)-tetrahydro-2-furanylmethyl]amino}methyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate, substituting 2-methyl-1-butanamine (45 mg, 0.525 mmol) for 1-[(2S)-tetrahydro-2-furanyl]methanamine to afford 30.5 mg of the title compound (54.5%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063071B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-52738ab12e924f1cbb9e91267f487aa3 |
| 출처 메모 | uspto-grants-2011_11 |