Ammonia → (Z)-3-amino-N-(3-trifluoromethyl-4-morpholinophenyl)but-2-enamide
반응식
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([NH:15][C:16](=[O:21])[CH2:17][C:18](=O)[CH3:19])[CH:6]=[CH:7][C:8]=1[N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1.[NH3:24]>CO>[NH2:24]/[C:18](/[CH3:19])=[CH:17]\[C:16]([NH:15][C:5]1[CH:6]=[CH:7][C:8]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[C:3]([C:2]([F:23])([F:22])[F:1])[CH:4]=1)=[O:21]참가 물질
4
실험 절차
A mixture of N-(3-trifluoromethyl-4-morpholinophenyl)-3-oxobutanamide (4.0 g, 12.1 mmol), MeOH (20 mL) and ammonia (20 mL) was stirred at rt overnight. The mixture was then concentrated in vacuo to give the title compound, which was used for next step without further purification.
후처리
- concentrationThe mixture was then concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-ec3e13da603d435db0061cc3f8e97f5a
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434695B2
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