Ethanol → 4-(3-Fluorophenoxy)butanoic acid

HRID 56251

반응식

HRID 56251 반응식
[OH-].[K+].O.C(O)C.[F:7][C:8]1[CH:9]=[C:10]([CH:20]=[CH:21][CH:22]=1)[O:11][CH2:12][CH2:13][CH2:14][C:15]([O:17]CC)=[O:16]>C(Cl)Cl>[F:7][C:8]1[CH:9]=[C:10]([CH:20]=[CH:21][CH:22]=1)[O:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16]

참가 물질

6

반응물 4

HCID 702EthanolHCID 962WaterHCID 14797Potassium HydroxideHCID 21812847Ethyl 4-(3-fluoro-phenoxy)butanoate

생성물 1

HCID 64860154-(3-Fluorophenoxy)butanoic acid수율 96%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
40 °C

실험 절차

To a solution of KOH (0.24 g, 4.28 mmol) in mixed solvents of water (3 mL) and ethanol (3 mL) under N2 was added ethyl 4-(3-fluorophenoxy)butanoate (0.30 g, 1.33 mmol) in one portion and the mixture was stirred at 40° C. for 4 h. It was then cooled to rt and 20 mL of DCM was added. The organic layer was washed with brine (20 mL×2), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a white solid (0.25 g, 96%).

후처리

  1. temperatureIt was then cooled to rt
  2. washThe organic layer was washed with brine (20 mL×2)
  3. dry with materialdried over anhydrous Na2SO4
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-fdaf1e14d6bf43bcbc8ae6ddeb79e2ae
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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