참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-(2-Carboxyethyl)benzeneboronic acid | HCID 3863484 | — |
| 반응물 | Tert-butyl 3-(4-bromophenyl)propanoate | HCID 10708234 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | Acetonitrile--water (1/1) | HCID 18373917 | — |
| 생성물 | tert-butyl 3-[4'-(2-Carboxy-ethyl)-biphenyl-4-yl]-propionate | HCID 66724435 | — |
반응 단계
Tert-butyl 3-(4-bromophenyl)propionate (433 mg, 1.52 mmol) in acetonitrile-water (3:1, 13 ml) under argon atmosphere was treated with 4-(2-carboxyethyl)benzeneboronic acid (294 mg, 1.52 mmol), K2CO3 (251 mg, 1.82 mmol) and (Ph3P)4Pd (87 mg, 73 μmol), and the stirred mixture was heated at 90° C. for 4 hours. Excess ethyl acetate and 2 M HCl was added and the organic phase was washed with 2×2 M HCl and 2× water. Drying over MgSO4 and evaporation in vacuo gave the crude product, which was purified by chromatography on silica column eluted with ethyl acetate/hexane/acetic acid 50:50:1 to provide tert-butyl 3-[4′-(2-Carboxy-ethyl)-biphenyl-4-yl]-propionate, 330 mg (62%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08067362B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_11 |
|---|
| ORD ID | ord-b816e92ded954250ad8daa17a66f86cd |
|---|
| 출처 메모 | uspto-grants-2011_11 |
|---|
