Water → {[4-(5-Chloro-1,3-dioxobenzo [c]azolidin-2-yl)-3-methylphenyl]amino}-n-(phenylsulfonimidoyl)carboxamide

HRID 562665

반응식

HRID 562665 반응식
[Cl:1][C:2]1[CH:41]=[CH:40][C:5]2[C:6](=[O:39])[N:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][C:17]([NH:19][S:20]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)(=[N:22]CC4C=CC(OC)=CC=4)=[O:21])=[O:18])=[CH:12][C:11]=3[CH3:38])[C:8](=[O:9])[C:4]=2[CH:3]=1.O.[N+]([O-])([O-])=O.[NH4+]>O=[N+]([O-])[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[Ce+4].[NH4+].[NH4+]>[Cl:1][C:2]1[CH:41]=[CH:40][C:5]2[C:6](=[O:39])[N:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][C:17]([NH:19][S:20]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)(=[NH:22])=[O:21])=[O:18])=[CH:12][C:11]=3[CH3:38])[C:8](=[O:9])[C:4]=2[CH:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 22985Ammonium nitrateHCID 20799232{[4-(5-Chloro-1,3-dioxobenzo[c]azolidin-2-yl)-3-methylphenyl]-amino}-n-(n-p-methoxybenzylphenylsulfonimidoyl)carboxamide

생성물 1

HCID 20799234{[4-(5-Chloro-1,3-dioxobenzo [c]azolidin-2-yl)-3-methylphenyl]amino}-n-(phenylsulfonimidoyl)carboxamide

시약·촉매·용매 1

HCID 180504Ceric ammonium nitrate용매

실험 절차

To 10 mg (0.016 mmol) of {[4-(5-chloro-1,3-dioxobenzo[c]azolidin-2-yl)-3-methylphenyl]-amino}-N-(N-p-methoxybenzylphenylsulfonimidoyl)carboxamide dissolved in 380 μL of CAN followed by 96 uL of water was added 70 mg (0.13 mmol) of cerric ammonium nitrate. After 20 m, the reaction was complete and purified by RP-HPLC to give 1.8 mg (23%) after lyophilization. ES-MS (M+H)+=469 (Cl).

후처리

  1. custompurified by RP-HPLC
  2. customto give 1.8 mg (23%) after lyophilization

출처 및 근거

ORD 기록
ord-e9adf39cbd6046beb1ec5daccc9b5596
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067428B2

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