Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → n-[(5-Chloro(2-thienyl))sulfonyl](4-nitrophenyl)carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Nitrobenzoyl chloride | HCID 8502 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 5-Chlorothiophene-2-Sulfonamide | HCID 1241301 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | n-[(5-Chloro(2-thienyl))sulfonyl](4-nitrophenyl)carboxamide | HCID 22064472 | 81% |
반응 단계
A 85 mg portion (0.43 mmol) of 5-chlorothiophenesulfonamide dissolved in 2 mL of acetone was treated with 110 μL of 4N NaOH (0.43 mmol) followed by addition of 80 mg (0.43 mmol) of 4-nitrobenzoyl chloride. After stirring for 12 h, the solution was acidified 1N HCl and the precipitate was collected by filtration and dried. Recrystallization from EtOAc/hexane afforded 120 mg (81%) of the titled compound. ES-MS (M+H)+=347 (Cl).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08067428B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-7cb847189dff412ea02acc053bd54848 |
| 출처 메모 | uspto-grants-2011_11 |