참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tert-Butylamine | HCID 6385 | — |
| 반응물 | 5-Chlorothiophene-2-sulfonyl chloride | HCID 2733925 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-Chlorothiophene-2-sulfonic acid tert-butylamide | HCID 10106323 | 98% |
반응 단계
A solution of 5.5 g (27.5 mmol) of 5-chlorothiophenesulfonyl chloride in dry THF at 0° C. was treated with a solution of 5.7 mL (75.5 mmol) of t-butylamine. After warming to 23° C., the reaction mixture was diluted with 125 mL of diethyl ether, filtered, and washed with 1 N HCl, brine, and dried (MgSO4). Concentration in vacuo affords 6.4 g (98%) of the named compound as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08067428B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_11 |
|---|
| ORD ID | ord-84b2ae8fa58f4456bf99d9bc6dff0e5a |
|---|
| 출처 메모 | uspto-grants-2011_11 |
|---|
