2-(Cyclobutyloxy)-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine → 2-(Cyclopentyloxy)-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

반응식

[CH:1]1([O:5][C:6]2[N:14]=[C:13]3[C:9]([N:10]=[C:11]([O:21][CH3:22])[N:12]3[CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][O:16]3)=[C:8]([NH2:23])[N:7]=2)[CH2:4][CH2:3][CH2:2]1.Br[C:25]1N(C2CCCCO2)C2C(N=1)=C(N)N=C(OC1CCCC1)N=2>>[CH:1]1([O:5][C:6]2[N:14]=[C:13]3[C:9]([N:10]=[C:11]([O:21][CH3:22])[N:12]3[CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][O:16]3)=[C:8]([NH2:23])[N:7]=2)[CH2:2][CH2:25][CH2:3][CH2:4]1

참가 물질

반응물 2

HCID 592526012-(Cyclobutyloxy)-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

HCID 592526558-Bromo-2-(cyclopentyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

생성물 1

HCID 592525592-(Cyclopentyloxy)-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

실험 절차

Prepared similarly to Intermediate 57 from 8-bromo-2-(cyclopentyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine.

출처 및 근거

ORD 기록: ord-b4e54e908cf945639bd87650844002ae
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08067426B2

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