Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Fluorophenol → 2-(3-Fluorophenoxy)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Fluorophenol | HCID 9743 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromoacetamide | HCID 69632 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 2-(3-Fluorophenoxy)acetamide | HCID 18938105 | 30% |
반응 단계
A mixture of 3-fluorophenol (11.2 g, 100 mmol), 2-bromoacetamide (13.8 g, 100 mmol), K2CO3 (13.82 g, 100 mmol) and Cs2CO3 (32.58 g, 100 mmol) in acetone (150 mL) was refluxed overnight. The mixture was cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid (5.06 g, 30%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434695B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-7eb07fbcc8ef449b86ac184e3c4a8ea6 |
| 출처 메모 | uspto-grants-2016_09 |