Methanol → 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid

HRID 562851노트

반응식

HRID 562851 반응식
C([O:8][C:9]([C:11]1[CH:12]=[C:13]2[CH:19]=[CH:18][NH:17][C:14]2=[N:15][CH:16]=1)=[O:10])C1C=CC=CC=1.CO>[OH-].[Pd+2].[OH-].[Pd]>[NH:17]1[C:14]2=[N:15][CH:16]=[C:11]([C:9]([OH:10])=[O:8])[CH:12]=[C:13]2[CH:19]=[CH:18]1

참가 물질

5

반응물 2

HCID 887MethanolHCID 57595581Benzyl 1H-pyrrolo[2,3-b]pyridine-5-carboxylate

생성물 1

HCID 219070181H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 9942167Palladium hydroxide촉매

실험 절차

Into a round bottom flask was added compound 22 (55.0 mg, 0.000218 mol) and palladium hydroxide, 20 wt. % Pd on carbon, wet (20.0 mg, 0.000142 mol) and Methanol (5.0 mL, 0.12 mol) under an atmosphere of Hydrogen. The reaction mixture was stirred at room temperature overnight. Filtration and concentration gave product 15 (35 mg).

후처리

  1. filtrationFiltration and concentration

출처 및 근거

ORD 기록
ord-a4d78e4337944a3c824efa5de88762ff
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067434B2

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