참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Morpholinone | HCID 66953 | — |
| 반응물 | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-(2-Fluoro-4-nitrophenyl)morpholin-3-one | HCID 23105382 | 42% |
반응 단계
A mixture of 1,2-difluoro-4-nitrobenzene (7.95 g, 50.0 mmol), morpholin-3-one (5.06 g, 50.0 mmol) and K2CO3 (13.82 g, 100 mmol) in DMF (80 mL) was stirred at 140° C. overnight. The mixture was cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=3:1) to give the title compound as a yellow solid (5.00 g, 42%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09434695B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-0f6ede62165a4a7eb45a4e1fb1e3c955 |
|---|
| 출처 메모 | uspto-grants-2016_09 |
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