Pentamethylbenzene → Methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate

HRID 562888

반응식

HRID 562888 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[C:17]([CH:22]=[CH:23][N:24]=2)[C:18]([O:20][CH3:21])=[O:19])=[CH:11][C:10]=1[C:25]#[N:26])C1C=CC=CC=1.CC1C(C)=C(C)C(C)=C(C)C=1>FC(F)(F)C(O)=O>[C:25]([C:10]1[CH:11]=[C:12]([C:15]2[CH:16]=[C:17]([CH:22]=[CH:23][N:24]=2)[C:18]([O:20][CH3:21])=[O:19])[CH:13]=[CH:14][C:9]=1[OH:8])#[N:26]

참가 물질

4

반응물 2

HCID 12784PentamethylbenzeneHCID 66995135Methyl 2-[4-(benzyloxy)-3-cyanophenyl]isonicotinate

생성물 1

HCID 136368377Methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

Methyl 2-[4(benzyloxy)-3-cyanophenyl]isonicotinate and pentamethylbenzene were heated under reflux temperature in trifluoroacetic acid to obtain methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate. F: 255.

출처 및 근거

ORD 기록
ord-b435b5fd0d6c49fc90b0c27c34855dbd
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067446B2

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