참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Fluorophenol | HCID 9743 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Ethyl bromodifluoroacetate | HCID 69585 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate | HCID 66455005 | — |
반응 단계
A mixture of 3-fluorophenol (2.24 g, 20.0 mmol), ethyl 2-bromo-2,2-difluoroacetate (8.12 g, 40.0 mmol) and K2CO3 (6.91 g, 50.0 mmol) in MeOH (20 mL) was stirred at 70° C. overnight. It was then cooled to rt and filtered and the filtrate was concentrated in vacuo to give the title compound, which was used for next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09434695B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-47bd33ea822e493bb4ab17fa47d0f8ef |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
