Ibuprofen, (+-)- → HCID 178440860, 화합물

HRID 563048

반응식

[CH:1]1[S:5][C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[N:3][C:2]=1[CH2:10][S:11][CH2:12][CH2:13][C:14]([NH:16][S:17]([NH2:20])(=[O:19])=[O:18])=[NH:15].[OH:21][C:22]([CH:24]([C:26]1[CH:35]=[CH:34][C:29]([CH2:30][CH:31]([CH3:33])[CH3:32])=[CH:28][CH:27]=1)[CH3:25])=[O:23]>>[OH:23][C:22]([CH:24]([C:26]1[CH:27]=[CH:28][C:29]([CH2:30][CH:31]([CH3:32])[CH3:33])=[CH:34][CH:35]=1)[CH3:25])=[O:21].[CH:1]1[S:5][C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[N:3][C:2]=1[CH2:10][S:11][CH2:12][CH2:13][C:14]([NH:16][S:17]([NH2:20])(=[O:19])=[O:18])=[NH:15]

참가 물질

반응물 2

HCID 3672Ibuprofen, (+-)-

HCID 178418935HCID 178418935, 화합물

생성물 1

HCID 178440860HCID 178440860, 화합물

실험 절차

The famotidine granules are mixed with ibuprofen granules (prepared as described in Table 27, infra) in a proportion that results in an ibuprofen:famotidine (800:26.6) mixture. Colliodal silicon dioxide, croscarmellose, silicified microcrystalline cellulose, and magnesium stearate are added to the ibuprofen-famotidine mixture, and the resulting mixture is compressed into tablets containing 800 mg ibuprofen and 26.6 mg famotidine (calculated weight).

출처 및 근거

ORD 기록: ord-3523603347704f0dae417da10e8f218f
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08067451B2

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