Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 563063생성일: 2026년 10월 25일
Dimethylformamide → 4-(4-Chlorophenyl)-2-(4,5-diphenyl-1-imidazolyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole
https://huagongshe.com/reaction/563063
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4,5-Diphenylimidazole | HCID 69588 | — |
| 반응물 | 2-Chloro-4-(4-chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole | HCID 10959800 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(4-Chlorophenyl)-2-(4,5-diphenyl-1-imidazolyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole | HCID 18174684 | 46% |
반응 단계
A mixture of 2-chloro-4-(4-chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole (378 mg), 4,5-diphenylimidazole (270 mg), anhydrous potassium carbonate (220 mg) and N,N-dimethylformamide (10 ml) was stirred at 100° C. for 12 hours. The reaction mixture was poured into water, the resulting solid precipitate was filtered and air-dried. Recrystallization of this solid from acetone-isopropyl ether gave 4-(4-chlorophenyl)-2-(4,5-diphenyl-1-imidazolyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole as pale yellow prisms (220 mg, 46%). Melting point 118-119° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08067453B2 |
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| 출처 데이터셋 | uspto-grants-2011_11 |
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| ORD ID | ord-5090f730dd7b4db08ddd882a620d8aeb |
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| 출처 메모 | uspto-grants-2011_11 |
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