Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-tert-butyl-1-methyl-1H-pyrazole-5-carboxylic acid → 2-[4-(5-tert-Butyl-2-methyl-2H-pyrazole-3-carbonyl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-tert-butyl-1-methyl-1H-pyrazole-5-carboxylic acid | HCID 720529 | — |
| 반응물 | 1-(4-Fluorophenyl)-2-(piperazin-1-yl)ethan-1-one dihydrochloride | HCID 42933716 | — |
| 생성물 | 2-[4-(5-tert-Butyl-2-methyl-2H-pyrazole-3-carbonyl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-ethanone | HCID 24810976 | 91.9% |
반응 단계
The title compound was prepared in a similar manner as described in Example 1.2, using 3-tert-butyl-1-methyl-1H-pyrazole-5-carboxylic acid (27.3 mg), and 1-(4-fluorophenyl)-2-(piperazin-1-yl)ethanone dihydrochloride (29.5 mg) as starting materials, to afford the title compound (35.5 mg) as a yellow solid. Exact mass calculated for C21H27FN4O2: 386.2. Found: LCMS m/z=387.5 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434692B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-96434d945b19418f81d8c3ae2719b1d7 |
| 출처 메모 | uspto-grants-2016_09 |