2-Bromo-5-(trifluoromethyl)benzaldehyde → 1-(2-Bromo-5-(trifluoromethyl)phenyl)ethanol

HRID 563504노트

반응식

HRID 563504 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:14][Mg]I>C1COCC1>[Br:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:11])([F:12])[F:13])=[CH:6][C:3]=1[CH:4]([OH:5])[CH3:14]

참가 물질

4

반응물 2

HCID 70180472-Bromo-5-(trifluoromethyl)benzaldehydeHCID 178418373HCID 178418373, 화합물

생성물 1

HCID 574587951-(2-Bromo-5-(trifluoromethyl)phenyl)ethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To 2-bromo-5-trifluoromethyl-benzaldehyde (1.0 g, 3.95 mmol) in THF (10 mL) at 0° C. under N2 was added methylmagnesium iodide (3M in diethyl ether; 2.6 mL, 7.91 mmol). The reaction was stirred for 2 hours, and then quenched with saturated aqueous NH4Cl and diluted with CH2Cl2. The aqueous layer was separated and extracted with CH2Cl2, and the combined organic layers were dried over MgSO4, filtered, and concentrated to give the title compound.

후처리

  1. customquenched with saturated aqueous NH4Cl
  2. additiondiluted with CH2Cl2
  3. customThe aqueous layer was separated
  4. extractionextracted with CH2Cl2
  5. dry with materialthe combined organic layers were dried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-93bd496e92be4f5bb50fb3d66fae6485
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067445B2

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