Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → 3-Bromo-4-hydroxyphenylacetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | 3-Bromo-4-methoxyphenylacetic acid | HCID 136615 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 3-Bromo-4-hydroxyphenylacetic acid | HCID 2769628 | — |
반응 단계
3-Bromo-4-methoxyphenylacetic acid (1.3 g, 5.6 mmol) was heated in a solution of hydrogen bromide (3 mL) and acetic acid (3 mL) at 100° C. overnight. The mixture was then partitioned between EtOAc and H2O, and the aqueous layer was separated and extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered, and concentrated to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08067445B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-aa313f2ce17b461c8e45403b4c2cb189 |
| 출처 메모 | uspto-grants-2011_11 |