(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester → (3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

HRID 563551노트

반응식

HRID 563551 반응식
[CH3:1][O:2][C:3](=[O:23])[CH2:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([O:15]CC2C=CC=CC=2)[CH:6]=1>CCO.[Pd]>[CH3:1][O:2][C:3](=[O:23])[CH2:4][C:5]1[CH:10]=[C:9]([C:11]([F:12])([F:14])[F:13])[CH:8]=[C:7]([OH:15])[CH:6]=1

참가 물질

4

반응물 1

HCID 58149337(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

생성물 1

HCID 59644745(3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester (4.8 mmol) in EtOH was treated with 10% palladium on carbon (10% by weight), and stirred under a balloon of H2 at 60° C. overnight. The mixture was filtered to remove the palladium, and then concentrated to give the title compound.

후처리

  1. filtrationThe mixture was filtered
  2. customto remove the palladium
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2475c029a7d74009a6c469174bb1c4f8
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067445B2

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