Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Clofibric Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Clofibrate | HCID 2796 | — |
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Clofibric Acid | HCID 2797 | — |
반응 단계
A solution of 2-(4-chlorophenoxy)isobutyric acid ethyl ester (1.0 g, 4.12 mmol) in THF (10 mL) was treated with 1N aqueous LiOH (10 mL) and stirred overnight at room temperature. The mixture was acidified with 1N aqueous HCl to pH 3-4 and extracted three times with EtOAc. The combined organic layers were dried and concentrated to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08067445B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-534f193b409a4a5697970c15e0961994 |
| 출처 메모 | uspto-grants-2011_11 |