Ethanol → Ethyl 4-bromo-3-methylbenzoate
반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[CH3:11].S(Cl)(Cl)=O.[CH3:16][CH2:17]O>>[CH2:16]([O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([Br:1])=[C:3]([CH3:11])[CH:4]=1)[CH3:17]참가 물질
4
실험 절차
To 4-bromo-3-methylbenzoic acid (3 g, 14 mmol) in EtOH (200 mL) was added thionyl chloride (2 mL, 25 mmol), and the reaction was stirred for 10 minutes. Additional thionyl chloride (3 mL, 35 mmol) was added, and the reaction was stirred overnight at 50° C. After cooling to room temperature, the mixture was quenched with the slow addition of powdered Na2CO3, and then filtered and concentrated. The residue was partitioned between EtOAc and H2O, and the organic layer was dried, filtered, and concentrated to give the title compound.
후처리
- stirringthe reaction was stirred overnight at 50° C
- customthe mixture was quenched with the slow addition of powdered Na2CO3
- filtrationfiltered
- concentrationconcentrated
- customThe residue was partitioned between EtOAc and H2O
- customthe organic layer was dried
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-aef2c2dc02544837b83e32250d5b87e9
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08067445B2
반응 노트
불러오는 중…