Methyl 2-(3-bromo-5-chlorophenyl)acetate → [2'-(3-Benzyl-1-ethyl-ureidomethyl)-5-chloro-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid methyl ester

HRID 563797노트

반응식

HRID 563797 반응식
[CH2:1]([NH:8][C:9](=[O:33])[N:10]([CH2:31][CH3:32])[CH2:11][C:12]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:13]=1B1OC(C)(C)C(C)(C)O1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:34][O:35][C:36](=[O:46])[CH2:37][C:38]1[CH:43]=[C:42]([Cl:44])[CH:41]=[C:40](Br)[CH:39]=1>>[CH3:34][O:35][C:36](=[O:46])[CH2:37][C:38]1[CH:39]=[C:40]([C:13]2[CH:14]=[CH:15][C:16]([C:18]([F:21])([F:19])[F:20])=[CH:17][C:12]=2[CH2:11][N:10]([CH2:31][CH3:32])[C:9]([NH:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[O:33])[CH:41]=[C:42]([Cl:44])[CH:43]=1

참가 물질

3

반응물 2

HCID 58149292Methyl 2-(3-bromo-5-chlorophenyl)acetateHCID 666071263-Benzyl-1-ethyl-1-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-urea

생성물 1

HCID 66607495[2'-(3-Benzyl-1-ethyl-ureidomethyl)-5-chloro-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid methyl ester

실험 절차

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: 3-benzyl-1-ethyl-1-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-urea and (3-bromo-5-chloro-phenyl)-acetic acid methyl ester.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-e0003c300403485fa8fe550c1a8b5582
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067445B2

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