Oxalyl chloride → 2-(3-Bromo-5-chloro-phenyl)-propionyl chloride
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]([CH3:13])[C:10](O)=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1.C(Cl)(=O)C([Cl:17])=O>C(Cl)Cl.CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]([CH3:13])[C:10]([Cl:17])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1참가 물질
5
실험 절차
To a solution of 2-(3-bromo-5-chloro-phenyl)-propionic acid (0.87 g, 3.3 mmol) in CH2Cl2 (10 mL) was added oxalyl chloride (0.63 mL, 6.6 mmol) and DMF (2 drops), and the reaction was stirred for 15 minutes and then concentrated to give the title compound.
후처리
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-fd91898b5e7341019e33578d5715a7a1
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08067445B2
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