Chlorosuccinimide → 2-chloro-2-methylthio-N-(2-methylpent-3-yn-2-yl)acetamide

HRID 563888노트

반응식

HRID 563888 반응식
[CH3:1][S:2][CH2:3][C:4]([NH:6][C:7]([CH3:12])([C:9]#[C:10][CH3:11])[CH3:8])=[O:5].[Cl:13]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Cl:13][CH:3]([S:2][CH3:1])[C:4]([NH:6][C:7]([CH3:12])([C:9]#[C:10][CH3:11])[CH3:8])=[O:5]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 860149882-(methylthio)-N-(2-methylpent-3-yn-2-yl)acetamide

생성물 1

HCID 866108822-chloro-2-methylthio-N-(2-methylpent-3-yn-2-yl)acetamide수율 143.3%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

반응 조건

온도
0 °C

실험 절차

The product of Step 1 (0.824 g) was dissolved in carbon tetrachloride (15 ml) with warming. The solution was then cooled to 0° C. and N-chlorosuccinimide (NCS, 0.653 g) was then gradually added and the mixture was stirred at ambient temperature for 2 hours. The reaction mixture was filtered to remove succinimide and the resulting liquid was evaporated to give 2-(chloro)-2-(methylthio)-N-(2-methylpent-3-yn-2-yl) acetamide as a clear oil (1.4 g), which was used without further purification.

후처리

  1. temperaturewith warming
  2. filtrationThe reaction mixture was filtered
  3. customto remove succinimide
  4. customthe resulting liquid was evaporated

출처 및 근거

ORD 기록
ord-3e105cff6cdb43a3a46d8d5a2a7bebfa
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067592B2

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