Benzoyl chloride, 2-chloro-5-nitro- → 2-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide

HRID 563998노트

반응식

HRID 563998 반응식
[NH:1]1[C:5]2=[N:6][CH:7]=[C:8]([NH2:10])[CH:9]=[C:4]2[CH:3]=[CH:2]1.[Cl:11][C:12]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:13]=1[C:14](Cl)=[O:15]>N1C=CC=CC=1.ClCCl>[Cl:11][C:12]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:13]=1[C:14]([NH:10][C:8]1[CH:9]=[C:4]2[CH:3]=[CH:2][NH:1][C:5]2=[N:6][CH:7]=1)=[O:15]

참가 물질

5

반응물 2

HCID 117637Benzoyl chloride, 2-chloro-5-nitro-HCID 117151871H-pyrrolo(2,3-b)pyridin-5-amine

생성물 1

HCID 670082132-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6344Dichloromethane용매

실험 절차

1.87 g 1H-Pyrrolo[2,3-b]pyridin-5-ylamine in 60 ml dry pyridine were treated dropwise at RT with a solution of 6.79 g 2-chloro-5-nitrobenzoyl chloride in 10 ml dichloromethane. Stirring was continued over night. The mixture was evaporated and the residue was treated with 25 ml methanol and 10 ml conc. ammonia for 2 hrs at RT. The solvents are again evaporated and the residue is dispersed in water. The crude product is isolated by filtration and washed thoroughly with water and diethylether.

후처리

  1. waitwas continued over night
  2. customThe mixture was evaporated
  3. additionthe residue was treated with 25 ml methanol and 10 ml conc. ammonia for 2 hrs at RT
  4. customThe solvents are again evaporated
  5. additionthe residue is dispersed in water

출처 및 근거

ORD 기록
ord-b130c912c1e941c7a65caef297bdae47
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067599B2

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