2-Amino-3,5-dinitropyridine → Pyridine-2,3,5-triamine

HRID 564001노트

반응식

HRID 564001 반응식
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([N+:11]([O-])=O)=[CH:4][N:3]=1>CO.C1COCC1.[Pd]>[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([NH2:11])=[CH:4][N:3]=1

참가 물질

5

반응물 1

HCID 5043402-Amino-3,5-dinitropyridine

생성물 1

HCID 14626209Pyridine-2,3,5-triamine수율 98.2%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

5 g 2-Amino-3,5-dinitropyridine in a mixture of 66 ml methanol and 33 ml THF were hydrogenated over 800 mg 10% palladium on charcoal at room temperature and atmospheric pressure. After the calculated amount of hydrogen was consumed, the catalyst was filtered off and the filtrate was concentrated under vacuum yielding 3.31 g of the crude product which was used for the next step without further purification.

후처리

  1. customAfter the calculated amount of hydrogen was consumed
  2. filtrationthe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-6e29d33d1009406391acf6a39d00ad7a
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067599B2

반응 노트

불러오는 중…