2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone → 2-Bromo-1-(3-fluoro-4-hydroxymethyl-phenyl)-ethanone

HRID 564070노트

반응식

HRID 564070 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][OH:12])=[CH:7][CH:6]=1)=[O:4].C([SiH2]OC(C)(C)C1C=CC(C(=O)C)=CC=1[F:29])(C)(C)C.[Br-].[Br-].[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC>>[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][OH:12])=[C:7]([F:29])[CH:6]=1)=[O:4]

참가 물질

4

반응물 3

HCID 197980532-Bromo-1-[4-(hydroxymethyl)phenyl]ethanoneHCID 23500184Tetra-n-butylammonium tribromideHCID 1317292941-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-3-fluoro-phenyl]-ethanone

생성물 1

HCID 866236862-Bromo-1-(3-fluoro-4-hydroxymethyl-phenyl)-ethanone

실험 절차

2-Bromo-1-(3-fluoro-4-hydroxymethyl-phenyl)-ethanone is prepared following preparation 15a from 280 mg (0.99 mmol) 1-[4-(tert-butyl-dimethyl-silanyloxymethyl)-3-fluoro-phenyl]-ethanone (preparation 16e) and 478 mg (0.99 mmol) tetrabutylammonium-tribromide.

출처 및 근거

ORD 기록
ord-14bf8311e809461d8ed5f4cb173c7c8c
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067590B2

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