2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone → 5-(5-Chloro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one

HRID 564075노트

반응식

HRID 564075 반응식
C(OC1C=CN([CH2:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][OH:25])=[CH:20][CH:19]=2)=[O:17])C(=O)C=1)C1C=CC=CC=1.[Cl:27][C:28]1[CH:29]=[CH:30][C:31]([CH2:34][O:35][C:36]2[CH:41]=[N:40][NH:39][C:38](=[O:42])[CH:37]=2)=[N:32][CH:33]=1.BrCC(C1C=CC(CO)=CC=1)=O>>[Cl:27][C:28]1[CH:29]=[CH:30][C:31]([CH2:34][O:35][C:36]2[CH:41]=[N:40][N:39]([CH2:15][C:16]([C:18]3[CH:23]=[CH:22][C:21]([CH2:24][OH:25])=[CH:20][CH:19]=3)=[O:17])[C:38](=[O:42])[CH:37]=2)=[N:32][CH:33]=1

참가 물질

4

반응물 3

HCID 197980532-Bromo-1-[4-(hydroxymethyl)phenyl]ethanoneHCID 670068424-Benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-oneHCID 670071055-(5-chloro-pyridin-2-ylmethoxy)-2H-pyridazin-3-one

생성물 1

HCID 670078515-(5-Chloro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one

실험 절차

5-(5-Chloro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one is prepared following preparation 15b from 450 mg (1.89 mmol) 5-(5-chloro-pyridin-2-ylmethoxy)-2H-pyridazin-3-one (preparation 18b) and 477 mg (2.08 mmol) 2-bromo-1-(4-hydroxymethyl-phenyl)-ethanone (preparation 15a).

출처 및 근거

ORD 기록
ord-51bfa1126ceb45ff83ed1f1c81582f51
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067590B2

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