(5-Fluoropyridin-2-yl)methanol → 5-(5-Fluoro-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one

HRID 564077노트

반응식

HRID 564077 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]([CH2:8][O:9][C:10]2[CH:15]=[N:14][N:13]([CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][O:17]3)[C:12](=[O:22])[CH:11]=2)=[N:6][CH:7]=1.OC1C=NN(C2CCCCO2)C(=O)C=1.[F:37]C1C=CC(CO)=NC=1>>[F:37][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][O:9][C:10]2[CH:15]=[N:14][N:13]([CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][O:17]3)[C:12](=[O:22])[CH:11]=2)=[N:6][CH:7]=1

참가 물질

4

반응물 3

HCID 24729312(5-Fluoropyridin-2-yl)methanolHCID 579503555-Hydroxy-2-(2-tetrahydropyranyl)pyridazin-3(2H)-oneHCID 670065045-(5-Chloro-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one

생성물 1

HCID 580921945-(5-Fluoro-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one

실험 절차

5-(5-Fluoro-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one is prepared following preparation 18a from 2.40 g (12.2 mmol) 5-hydroxy-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one (see preparation 5a) and 1.56 g (12.2 mmol) (5-fluoro-pyridin-2-yl)-methanol

출처 및 근거

ORD 기록
ord-a63fd859e3df42539cebdaf0d78ae006
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067590B2

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