4-Fluorobenzyl chloride → 5-(4-Fluoro-benzyloxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one

HRID 564090노트

반응식

HRID 564090 반응식
BrC1C=CC(COC2C=NN(C3CCCCO3)C(=O)C=2)=NC=1.[OH:23][C:24]1[CH:29]=[N:28][N:27]([CH:30]2[CH2:35][CH2:34][CH2:33][CH2:32][O:31]2)[C:26](=[O:36])[CH:25]=1.Cl[CH2:38][C:39]1[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=1>>[F:45][C:42]1[CH:43]=[CH:44][C:39]([CH2:38][O:23][C:24]2[CH:29]=[N:28][N:27]([CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][O:31]3)[C:26](=[O:36])[CH:25]=2)=[CH:40][CH:41]=1

참가 물질

4

반응물 3

HCID 96024-Fluorobenzyl chlorideHCID 579503555-Hydroxy-2-(2-tetrahydropyranyl)pyridazin-3(2H)-oneHCID 670068655-(5-Bromo-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one

생성물 1

HCID 670074195-(4-Fluoro-benzyloxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one

실험 절차

5-(4-Fluoro-benzyloxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one is prepared following preparation 25a from 8.00 g (40.8 mmol) 5-hydroxy-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one (preparation 5a) and 5.4 mL (44.9 mmol) 1-chloromethyl-4-fluoro-benzene.

출처 및 근거

ORD 기록
ord-61920f33a03247b98990af191a16aeb6
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067590B2

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