N-but-3-en-1-yl-N-(4-methoxyphenyl)acrylamide → 1-(4-methoxyphenyl)-5,6-dihydropyridin-2(1H)-one
반응식
[CH2:1]([N:5]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)[C:6](=[O:9])[CH:7]=[CH2:8])[CH2:2]C=C>C(Cl)Cl.Cl[Ru](=CC1C=CC=CC=1)([P](C1CCCCC1)(C1CCCCC1)C1CCCCC1)([P](C1CCCCC1)(C1CCCCC1)C1CCCCC1)Cl>[CH3:17][O:16][C:13]1[CH:12]=[CH:11][C:10]([N:5]2[CH2:1][CH2:2][CH:8]=[CH:7][C:6]2=[O:9])=[CH:15][CH:14]=1참가 물질
4
반응 조건
- 온도
- 40 °C
실험 절차
To a solution of N-but-3-en-1-yl-N-(4-methoxyphenyl)acrylamide (180 mg, 0.78 mmol) in degassed methylene chloride (200 mL) was added Grubbs catalyst (32 mg, 0.039 mmol) and the mixture was heated to 40° C. overnight. All volatiles were removed and the resulting material was subjected to flash chromatography (Hexanes:EtOAc 1:1) to yield 1-(4-methoxyphenyl)-5,6-dihydropyridin-2(1H)-one (158 mg, 98%).