Urea → HCID 178517413, 화합물

HRID 56456

반응식

HRID 56456 반응식
[NH2:1][C:2]1[CH:9]=[C:8]([Cl:10])[C:7]([Br:11])=[CH:6][C:3]=1[CH:4]=O.[NH2:12][C:13](N)=[O:14]>>[Br:11][C:7]1[CH:6]=[C:3]2[C:2](=[CH:9][C:8]=1[Cl:10])[N:1]=[C:13]([OH:14])[N:12]=[CH:4]2

참가 물질

3

반응물 2

HCID 1176UreaHCID 894196802-Amino-5-bromo-4-chlorobenzaldehyde

생성물 1

HCID 178517413HCID 178517413, 화합물

반응 조건

온도
180 °C

실험 절차

A mixture of 2-amino-5-bromo-4-chlorobenzaldehyde (5 g, 21.46 mmol) and urea (18 g, 300.0 mmol) was stirred at 180° C. for 5 hours. LCMS monitored the reaction was completed. The mixture was cooled to room temperature, washed with water (100 mL×3) and filtered. The filtration cake was dried to get the title compound as a yellow solid (6 g (crude, 100%). MS (ES+) C8H4BrClN2O requires: 258, 260, found: 259, 261 [M+H]+.

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. washwashed with water (100 mL×3)
  3. filtrationfiltered
  4. customThe filtration cake was dried

출처 및 근거

ORD 기록
ord-f79702e4626c493788d23e68740f9c30
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434700B2

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