Potassium Carbonate → 1,1-Dimethylethyl 4-[(3'-cyano-3-biphenylyl)methylidene]-1-piperidinecarboxylate

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	1,4-Dioxane	HCID 31275	—
반응물	Tert-butyl 4-(3-bromobenzylidene)piperidine-1-carboxylate	HCID 57813409	—
촉매	HCID 178418397	HCID 178418397	—
용매	Water	HCID 962	—
생성물	1,1-Dimethylethyl 4-[(3'-cyano-3-biphenylyl)methylidene]-1-piperidinecarboxylate	HCID 67005869	86%

반응 조건

온도	130 °C

반응 단계

To 1,1-dimethylethyl 4-[(3-bromophenyl)methylidene]-1-piperidinecarboxylate (2.11 g, 5.99 mmol) in 1,4-dioxane (30 mL) and water (10.00 mL) was added m-NC(C6H4)B(OH)2 (1.056 g, 7.19 mmol), Pd(Ph3P)4 0.277 g, 0.240 mmol), and K2CO3 (2.483 g, 17.97 mmol). The resultant mixture was split into two equal portions and each portion was heated in a microwave at 130° C. for 15 min. The reaction mixture was concentrated by Glas-Col evaporator and purified with CombiFlash chromatograph to afford the title compound (1.93 g, 86%). LC-MS m/z 749 (2M+H)+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08067408B2
출처 데이터셋	uspto-grants-2011_11
ORD ID	ord-30601844cad54c518aefb18ae3cfb373
출처 메모	uspto-grants-2011_11