4-Amino-5-pyrimidinecarbonitrile → 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (5-cyanopyrimidin-4-yl)amide

HRID 564733노트

반응식

HRID 564733 반응식
[N+](C1C=CC(O[C:11]([C:13]2[C:14]3[CH:23]=[C:22]([CH2:24][CH3:25])[O:21][C:15]=3[C:16]([O:19][CH3:20])=[N:17][CH:18]=2)=[O:12])=CC=1)([O-])=O.[NH2:26][C:27]1[C:32]([C:33]#[N:34])=[CH:31][N:30]=[CH:29][N:28]=1>>[C:33]([C:32]1[C:27]([NH:26][C:11]([C:13]2[C:14]3[CH:23]=[C:22]([CH2:24][CH3:25])[O:21][C:15]=3[C:16]([O:19][CH3:20])=[N:17][CH:18]=2)=[O:12])=[N:28][CH:29]=[N:30][CH:31]=1)#[N:34]

참가 물질

3

반응물 2

HCID 7372084-Amino-5-pyrimidinecarbonitrileHCID 541193452-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester

생성물 1

HCID 443653302-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (5-cyanopyrimidin-4-yl)amide수율 58.2%

실험 절차

Starting from 2-ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (200 mg) and 4-aminopyrimidine-5-carbonitrile (84 mg). Purification by trituration with ethyl acetate and methanol gave the title compound (110 mg) as an off white solid.

후처리

  1. customPurification by trituration with ethyl acetate and methanol

출처 및 근거

ORD 기록
ord-1f803e18aa6941ada2a94ee8434d3e23
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06169090A

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