Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Amino-3,5-dichlorobenzonitrile → 7-Difluoromethoxy-2-ethylfuro[2,3-c]pyridine-4-carboxylic acid (2,6-dichloro-4-cyanophenyl)amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Amino-3,5-dichlorobenzonitrile | HCID 522706 | — |
| 반응물 | 7-Difluoromethoxy-2-ethylfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester | HCID 53891029 | — |
| 생성물 | 7-Difluoromethoxy-2-ethylfuro[2,3-c]pyridine-4-carboxylic acid (2,6-dichloro-4-cyanophenyl)amide | HCID 57114137 | 10.7% |
반응 단계
Starting from 7-difluromethoxy-2-ethylfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (100 mg) and 4-amino-3,5-dichlorobenzonitrile (99 mg). Purification by column chromatography on silica eluting with 1% methanol in dichloromethane afforded the title compound as a white solid (12 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06169090A |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-b44cebf235124847987b7aea7b1b76e0 |
| 출처 메모 | uspto-grants-2001_01 |