(6-Amino-3-bromo-2-fluorophenyl)methanol → 6-Amino-3-bromo-2-fluorobenzaldehyde
반응식
[NH2:1][C:2]1[C:7]([CH2:8][OH:9])=[C:6]([F:10])[C:5]([Br:11])=[CH:4][CH:3]=1>ClCCl.[O-2].[Mn+4].[O-2]>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[C:6]([F:10])[C:5]([Br:11])=[CH:4][CH:3]=1참가 물질
4
실험 절차
A suspension mixture of (6-amino-3-bromo-2-fluorophenyl)methanol (8.3 g, 37.72 mmol) and manganese(IV) oxide (19.68 g, 226.32 mmol) in dichloromethane (400 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title product as a light yellow solid (6.0 g, 73%), which was directly used in the next step without further purification. MS (ES+) C7H5BrFNO requires: 217, found: 218, 220 [M+H]+.
후처리
- filtrationThe solid was filtered off
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-155644f5eff84fe2bb149bba65187648
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434700B2
반응 노트
불러오는 중…