(4-Aminophenoxy)benzene → HCID 22112834, 화합물

HRID 564790

반응식

HRID 564790 반응식
[Cl:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([CH3:11])[C:4]=2[N:5]=[CH:6][N:7]=1.[O:12]([C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CC(O)C>[ClH:1].[CH3:11][C:8]1[C:4]2[N:5]=[CH:6][N:7]=[C:2]([NH:23][C:22]3[CH:21]=[CH:20][C:19]([O:12][C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[CH:25][CH:24]=3)[C:3]=2[S:10][CH:9]=1

참가 물질

4

반응물 2

HCID 8764(4-Aminophenoxy)benzeneHCID 27775864-Chloro-7-methylthieno(3,2-d)pyrimidine

생성물 1

HCID 22112834HCID 22112834, 화합물수율 80%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

4-Chloro-7-methylthieno[3,2-d]pyrimidine (commercially available from Maybridge Chemical Co. Ltd.) (0.185 g, 1.00 mmol) and 4-phenoxyaniline (0.210 g, 1.1 mmol) were reacted in 2-propanol (5 ml) for 2 hours according to Procedure A. The product was obtained as a yellow solid (0.294 g, 80%), m.p. 243-245° C.; (Found: C, 61.46; H, 4.27, N, 11.32. C19H15N3OS.HCl requires: C, 61.70; H, 4.36; N, 11.36%); δH [2H6]-DMSO 10.85 (1H, br s, NH), 8.78 (1H, s, 2-H), 8.05 (1H, 2, 6-H), 7.69 (2H, d, J 9, 2′-H, 6′-H), 7.42 (2H, t, J 9, 3″-H, 5″-H), 7.00-7.20 (5H, m, 3′-H, 5′-H, 2″-H, 4″-H, 6″-H), 2.43 (3H, s, 7-CH3); m/z (%) 333 (M+).

출처 및 근거

ORD 기록
ord-24e9a81322a3492eb588b013b24fc4a5
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06169091A

연결된 노트

불러오는 중…