HCID 22113417, 화합물 → 2(1H)-Pyridinone,6-(difluoromethyl)-(9CI)
반응식
C([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]([F:14])[F:13])[N:7]=1)(C)(C)C>ClCCl>[F:13][CH:12]([F:14])[C:8]1[NH:7][C:6](=[O:5])[CH:11]=[CH:10][CH:9]=1참가 물질
3
실험 절차
To a solution of 2-tert-butoxy-6-difluoromethylpyridine (4.3 g) in dichloromethane (25 ml) trifluoroacetic acid (2 ml) was added. The reaction was stirred for 16 hours and then concentrated. The residue was diluted with water and neutralised with sodium bicarbonate. The solid formed was extracted into ethyl acetate, dried and concentrated to give 6-difluoromethylpyrid-2-one (3.2 g, 72% yield) as a white solid; 1H NMR (270 MHz): δ 6.31, 6.53, 6.75 (1H,t), 6.56(1H,m), 6.75(1H,m), 7.52(1H,m), 12.5(1H,brs) ppm.
후처리
- concentrationconcentrated
- additionThe residue was diluted with water and neutralised with sodium bicarbonate
- customThe solid formed
- extractionwas extracted into ethyl acetate
- customdried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-2b22c98a82484b76bd814c4828eb6f7c
- 출처 데이터셋
- uspto-grants-2001_01
- 특허 번호
- US06169101A
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