Methanol → potassium 2-(4-(1H-pyrazol-1-yl)phenyl)-2-methoxyacetate

HRID 56495

반응식

HRID 56495 반응식
[N:1]1([C:6]2[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[CH:14](Br)(Br)Br.[OH-:18].[K+:19].[CH3:20][OH:21]>O1CCOCC1>[N:1]1([C:6]2[CH:13]=[CH:12][C:9]([CH:10]([O:11][CH3:14])[C:20]([O-:21])=[O:18])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[K+:19]

참가 물질

6

반응물 4

HCID 887Methanol2회HCID 5558BromoformHCID 14797Potassium HydroxideHCID 27764774-(1H-Pyrazol-1-yl)benzaldehyde

생성물 1

HCID 67388986potassium 2-(4-(1H-pyrazol-1-yl)phenyl)-2-methoxyacetate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a stirred solution of 4-(1H-pyrazol-1-yl)benzaldehyde (1.3 g, 7.55 mmol) and bromoform (0.85 mL, 9.75 mmol) in MeOH (10 mL) and dioxane (10 mL) was added dropwise a solution of potassium hydroxide (2.2 g, 39 mmol) in MeOH (10 mL) over 15 minutes. Stirring was then continued for 23 hours. The mixture was filtered through Celite, rinsed through with EtOAc and concentrated under reduced pressure to yield potassium 2-(4-(1H-pyrazol-1-yl)phenyl)-2-methoxyacetate as a light yellow solid (3.2 g) that was used without further purification. See U.S. Pat. No. 7,129,238.

후처리

  1. filtrationThe mixture was filtered through Celite
  2. washrinsed through with EtOAc
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-034ed94b6f7243d68a696cd0661a86e9
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434707B2

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