Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → methyl 1-(3-tert-butoxycarbonylaminopropyl)-1H-indole-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl 1H-indole-2-carboxylate | HCID 70992 | — |
| 반응물 | tert-butyl N-(3-iodopropyl)carbamate | HCID 11231463 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | methyl 1-(3-tert-butoxycarbonylaminopropyl)-1H-indole-2-carboxylate | HCID 10830411 | 27% |
반응 단계
The reaction was carried out in a manner similar to Reference Example 5 except for using 5.00 g (28.5 mmol) of methyl 2-indolecarboxylate, 1.26 g (31.4 mmol) of 60% sodium hydroxide, 12.3 g (43.2 mmol) of tert-butyl N-(3-iodopropyl)carbamate (prepared from 3-iodopropyl-amine and di-tert-butyl dicarbonate) and 60 ml of dimethylformamide. Thus, 2.54 g (27%) of methyl 1-(3-tert-butoxycarbonylaminopropyl)-2-indolecarboxylate was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06169107A |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-0897eb3eed3143c18f23b3bf0bddb633 |
| 출처 메모 | uspto-grants-2001_01 |