Ethyl 7-benzyloxy-4-chloro-1-methyl-2-indolecarboxylate → HCID 21194451, 화합물

HRID 564998노트

반응식

HRID 564998 반응식
C([O:8][C:9]1[CH:10]=[CH:11][C:12]([Cl:24])=[C:13]2[C:17]=1[N:16]([CH3:18])[C:15]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:14]2)C1C=CC=CC=1>[Pd].O1CCCC1>[Cl:24][C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[C:17]2[C:13]=1[CH:14]=[C:15]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:16]2[CH3:18]

참가 물질

4

반응물 1

HCID 21194304Ethyl 7-benzyloxy-4-chloro-1-methyl-2-indolecarboxylate

생성물 1

HCID 21194451HCID 21194451, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

The reaction was carried out in a manner similar to Reference Example 18 b) except for using 7.71 g (22.4 mmol) of ethyl 7-benzyloxy-4-chloro-1-methyl-2-indolecarboxylate, 0.50 g of 10% palladium/carbon and 150 ml of tetrahydrofuran. Ethyl 4-chloro-7-hydroxy-1-methyl-2-indolecarboxylate was thus obtained in the yield of 4.70 g (82.6%).

출처 및 근거

ORD 기록
ord-19e77d9575f747b6aee0ed8e94e72964
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06169107A

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