Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 5-Hydroxy-2-methoxypyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 5-Acetoxy-2-methoxypyridine | HCID 22451566 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-Hydroxy-2-methoxypyridine | HCID 11622335 | 53.4% |
반응 단계
To a solution of the 5acetoxy-2-methoxypyridine (600 mg, 3.59 mmol) in MeOH (10 mL) was added 1M aq. NaOH (10 mL, 10 mmol). After stirring at r.t. for 30 min, volatile solvent was removed in vacuo, acidified with HOAc and extracted with CHCl3(3×). The combind CHCl3 extracts were washed with H2O, dried (anhydrous MgSO4) and evaporated to give the title compound as a brown oil (240 mg, solidified on standing).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06169188A |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-7a0e6f87b72e498c8d540f671597e5da |
| 출처 메모 | uspto-grants-2001_01 |